Background Major depressive disorder is one of the most common, burdensome, and costly psychiatric disorders
worldwide in adults. Pharmacological and non-pharmacological treatments are available; however, because of
inadequate resources, antidepressants are used more frequently than psychological interventions. Prescription of
these agents should be informed by the best available evidence. Therefore, we aimed to update and expand our previous
work to compare and rank antidepressants for the acute treatment of adults with unipolar major depressive disorder.