Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis

Background Major depressive disorder is one of the most common, burdensome, and costly psychiatric disorders
worldwide in adults. Pharmacological and non-pharmacological treatments are available; however, because of
inadequate resources, antidepressants are used more frequently than psychological interventions. Prescription of
these agents should be informed by the best available evidence. Therefore, we aimed to update and expand our previous
work to compare and rank antidepressants for the acute treatment of adults with unipolar major depressive disorder.

Leave a Reply

Please Login to comment
2 Comment threads
2 Thread replies
Most reacted comment
Hottest comment thread
2 Comment authors
Adrian SmithAndrew Smith Recent comment authors
newest oldest most voted
Notify of
Andrew Smith
Andrew Smith

Long term studies have not thoroughly been done or analysed, to determine the long term side effects.