
Summary
Background Major depressive disorder is one of the most common, burdensome, and costly psychiatric disorders
worldwide in adults. Pharmacological and non-pharmacological treatments are available; however, because of
inadequate resources, antidepressants are used more frequently than psychological interventions. Prescription of
these agents should be informed by the best available evidence. Therefore, we aimed to update and expand our previous
work to compare and rank antidepressants for the acute treatment of adults with unipolar major depressive disorder.
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Anti depressants often fail to deal with the root cause of depression, but often act as more of a band aid solution. Although in the case of depleted neurotransmitters, supplementation can aid in a patient’s recovery.
Long term studies have not thoroughly been done or analysed, to determine the long term side effects.